The central dogma of molecular biology states that the flow of genetic information moves from DNA to RNA to protein. However, this classical view has been challenged by recent findings on various types of regulatory non-coding RNAs (ncRNAs) . For example, the human ENCODE project revealed that >80% of the human genome is transcribed while only 1% codes for proteins. By using Arabidopsis as a model, our lab studies the genomics and functions of various non-coding RNAs, with current focus on a group of tiny ncRNAs called small RNAs (this group includes microRNAs and various types of small interfering RNAs, siRNAs) . These small RNAs are 21-24nt in length and can modulate gene expression at either the transcriptional or post-transcriptional level. They play essential roles in numerous biological processes such as genome stability, development, physiology and immunity. In addition, we study long ncRNAs that are critical for proper plant development and responses to abiotic stresses.
Our experimental approaches include:
- Use both forward and reverse genetic approaches to reveal the biological functions of particular component in small RNA metabolism in vivo.
- Employ different high-throughput techniques to measure DNA, RNA, and proteins on a global scale.
- Use various biochemical approaches to explore the molecular mechanisms of different components in RNA silencing.
Join the Lab
Postdoctoral Positions are now available in our Lab. If you have strong background and interests in biochemistry, plant RNA biology or bioinformatics, you are welcome here to bring your talents into full play. Please send your CV to Professor Guodong Ren.
Graduate and undergraduate students positions are also open for you now. A number of projects on pathways and functions of various plants non-coding RNAs wait for you.
Our lab studies the genomics and functions of various non-coding RNAs, with current focus on a group of tiny ncRNAs called small RNAs.
Postdoctoral Positions, Graduate and undergraduate students positions are available in our lab.